CaMouse^® — Pioneering VHH Discovery

Watsonbio is proud to introduce CaMouse^®—a next-generation, chromosome-engineered mouse platform designed to revolutionize single-domain antibody (VHH) discovery. Engineered with endogenous immunoglobulin heavy chain (IgH) locus, CaMouse^® produces high-affinity, fully functional heavy-chain-only antibodies (HcAbs) in vivo. These antibodies contain VHHs (variable domains of heavy-chain antibodies), enabling direct access to a diverse, drug-like repertoire.

Why CaMouse^®?

Traditional VHH (nanobody) generation using llamas is labor-intensive, expensive, and logistically complex. In contrast, CaMouse^® offers a fast, scalable, and cost-effective alternative by combining:

• The power of the natural immune system
• The genetic and immunological tractability of mice

Validated across a wide array of antigens (case studies available upon request) —CaMouse^® consistently deliver HcAbs with excellent solubility, stability, and specificity. Their compatibility with serum-free expression systems ensures rapid production of recombinant HcAbs suitable for research, diagnostics, and therapeutic development.

This innovative platform integrates seamlessly with established workflows, including:

• Hybridoma technology
• Phage and yeast display
• Single B-cell screening
• Direct VHH repertoire cloning

This innovative approach delivers superior consistency, reproducibility, and throughput across the antibody discovery process.

Applications

Whether your goal is to develop next-generation biologics, advanced diagnostics, or cutting-edge imaging tools, CaMouse^® provides the ideal platform to accelerate your nanobody pipeline — from discovery to development.

Discover the future of antibody engineering with CaMouse^® — where innovation meets accessibility.